Purpose: To evaluate the effect of ocular LLLT on structure and function in glaucomatous patients.

Methods: In this interventional case series, 12 eyes of 6 Iranian subjects were included. A diet rich in antioxidants were prescribed for all participants. LLLT was applied to the fovea, posterior pole, and occipital region. The regime of application of LLLT was 6 sessions every other day for 12 days, 30 days

off, 3 sessions every other day for 6 days, 90 days off and finally 3 sessions every other day for 6 days. Evaluation of central 24 degrees of the visual field by Swedish Interactive Thresholding Algorithm (SITA), peripapillary Retinal Nerve Fiber Layer (RNFL), and macular ganglion cell complex (GCC) was done before and 4 months after the intervention.

Results: The mean age and intraocular pressure (IOP) were 54.8 ± 7.3 years and 15.9 ± 4.1 mmHg respectively. After treatment mean deviation (MD) of visual field improved from -6.25 dB (-24.48 to-0.1) (Median (Range)) to -2.78 dB (-21.5 to -0.18). There was no significant difference in the global RNFL and GCC thickness before and after the intervention.

Conclusion: LLLT can significantly improve the visual function of glaucomatous patients.